It is nearly a given buy 400mg norfloxacin overnight delivery, however norfloxacin 400mg for sale, that all septic patients are not the same order 400mg norfloxacin fast delivery, and strate- gies that might be effective in one patient population would be ineffective or harm- ful in a different patient population of septic patients purchase norfloxacin cheap. There is signifcant preclinical literature demonstrating that the identical intervention can have signifcant differ- ences in effcacy depending on a variety of host variables [52–57]. Further, there is emerging data that endotypes exist in which patients have a different and disparate response to sepsis [58–60]. In the future, a multipronged engine aimed at precision has been proposed including (a) optimizing patient stratifcation and identifying poten- tial targets; (b) running in silico trials, confrming targets, and examining and refn- ing mechanisms in both cells and rodents; and (c) evaluating large mammal, which then loops back on optimizing patient stratifcation . The road ahead will assur- edly look more similar to oncology where patients are enrolled in clinical trials based upon molecular signatures and/or “omics” (genomics, transcriptomics, pro- teomics, or metabolomics) criteria as well as related criteria. The gold standard study to date in sepsis has generally been considered to the randomized controlled trial using mortality as an endpoint. In contrast, adaptive trial design can increase trial effciency by discarding ineffective doses or drugs or by increasing arms with a higher likelihood of success . Trial designs can use either predictive enrich- ment with patients based on likelihood of treatment response independent of disease severity or prognostic enrichment with a patient population at high risk of outcome event (or both) . The defnition of life-threatening is subjective, but the details of how to predict this are generally covered above. Infection is generally suspected by nonspecifc fnd- ings such as altered temperature and white blood cell count and less commonly by organ dysfunction without a clear etiology. This leaves a large opportunity for the future in that in many ways, the manner in which infection is either suspected or diagnosed has not changed in decades, resulting in the very real limitation of lack of specifcity for suspecting infection and lack of both accuracy and timeliness in diag- nosing infection. For example, blood cultures are positive in approximately one third of septic patients , and half of septic patients are culture negative . Further, those that are culture positive require a time frame of days for full sensitivi- ties to result after samples are manually streaked on an agar plate. This has signif- cant implications for antibiotic stewardship and also can cause delays in therapy—associated with increased mortality—if initial broad-spectrum antibiotics are not effective against the pathogen that is ultimately cultured. While Sepsis 3 intentionally did not comment on the defnition of infection , the road forward will almost certainly result in both more accurate diagnosis of infection and the capacity to diagnose infection in a much shorter time frame than is commonly done at the bedside. Although an overview of advances in diagnostic microbiology is outside the scope of this chapter, it is important to note that numerous rapid micro- bial pathogen tests using modern technology are being developed and tested in patients which can identify pathogens more accurately and rapidly than current techniques [72–78]. Complementary to more rapid and effective diagnosis of infection is more rapid and effective diagnosis of sepsis. Since earlier therapy of sepsis has been associated with improved outcomes, it stands to reason that if sepsis can be diagnosed (and hence treated) before signs and symptoms are obvious to the healthcare team, many of the more morbid complications of sepsis can potentially be attenuated or even prevented. Analysis of “big data” for patterns within easily accessible data that are not obvious to the bedside practitioner is a feld that is in its infancy but holds tremen- dous promise. A few recent studies have demonstrated that it is feasible to predict sepsis prior to clinical manifestations occurring. Similarly, a machine learning approach using multivariable combinations of easily obtained data was superior to other sepsis screening tools both in detecting sepsis at onset and 1–4 h preceding sepsis onset, even when 60% of input data was missing . The road ahead will almost certainly incorporate “big data” and complex systems into predictive algorithms that will transform the way sepsis is identifed. While there is obvious utility to examining gross organ dysfunction, it is likely that we are missing insights on a cellular or subcellular level that might be critical in understanding or treating sepsis. For instance, it is likely that intracellular bioener- getics, cell death (apoptosis, necrosis, pyroptosis, autophagy), barrier function, and functional status of cells (activated, naive, memory, exhausted, etc. The tools for measuring each of these currently exist in animal models, and some are being used experimentally in patients. The transition of understanding and measurement of organ dysfunction to a more cellular and subcellular level will likely occur in the intermediate to long-term future as deeper understanding of these (and many other) processes reach maturity and real- time assays allow their measurement at the bedside. Similarly, measuring a dysregu- lated host response (as opposed to an adaptive regulated host response) is currently impossible at the bedside. A tremendous number of possibilities exist for monitoring and modulating both organ function and the host response to infection that are out- side the scope of this chapter; however, we will briefy highlight two especially promising areas of research that will guide the road ahead in sepsis. The microbiome is the ecological community of microorganisms that reside in the whole body. The most intensively studied branch is the gut microbiome which consists of 40 trillion microbes, as many cells as we have in our bodies . Within 6 h of the onset of sepsis , the microbiome is converted into the “pathobiome” [84, 85] which is highlighted by (a) a loss of microbial diversity, (b) dominance of pathogenic micro- organisms, and (c) alterations in bacteria present to become more virulent [86, 87]. Together, these induce extremely low microbial diversity which is associated with worse outcomes in sepsis patients [84–86]. Each of these has been demon- strated to improve patient-centric outcomes such as ventilator-associated pneumo- nia, diarrhea, and mortality. However, our understanding of the microbiome is still very much in the nascent stage. The road ahead will allow us to understand our inner microbial community on a cellular and subcellular level and how to potentially modulate this community in a precision manner to improve outcomes in a more targeted, mechanistic method. Historically, many trials have attempted to decrease the pro-infammatory response in sepsis. While this approach has often been successful in preclinical trials of inbred mice when the precise time of onset of sepsis is known, they have generally been unsuccessful in septic patients . This can lead to secondary infection in the immunosuppressive stage of sepsis, which is a common cause of late death in sepsis [104, 105]. Notably, co-inhibitor blockade is associated with improved survival in multiple preclinical models of sepsis. While clinical trials examining co-inhibitory blockade in septic patients are just beginning to enroll patients, immune augmentation represents an attractive strategy in the future for sepsis. Further, a better understanding of a patient’s immune status (pro- infammatory, anti-infammatory, exhausted, immunosuppressed, etc. Sixteen (53%) of the 30 patients survived, 73% in group 1, 60% in group 2, and 36% in group 3. Survival correlated well with age less than 50 and the absence of multiple organ failure. The authors emphasized that the technique was easy to perform, avoiding many of the pitfalls previously reported. They pointed out that the absorbable polyglycolic acid (Dexon®) was found superior to the nonabsorbable polypropylene mesh. In 1989, this group presented their second series to the Eastern Association for the Surgery of Trauma and published it in 1990 . Some kept the abdomen closed in between procedures; others used various closure techniques such as retention sutures, slide fasteners, zippers, and Velcro adhesive sheets or towel clips. In 1993, the Surgical Infection Society carried out a prospective, open, consecutive, nonrandomized trial to examine management 1 Open Abdomen: Historical Notes 7 techniques and outcome in severe peritonitis . There was no signifcant difference in mortality between patients treated with a “closed abdomen technique” (31% mortal- ity) and those treated with variations of the “open abdomen” technique (44% mor- tality). Factors indicative of progressive or persistent organ failure during early postoperative follow-up were shown to be the best indicators for ongoing infection and were associated with posi- tive fndings at relaparotomy . Planned relaparotomy did not, therefore, lose its indication for selected patients. A majority of these patients were being seen at the end of their physiologic reserve, a situation called “physio- logic exhaustion. This truly heralded a new era in the management of the most severely injured and ill patients. Specifcally, the practice of supranormal oxygen delivery as an endpoint of adequacy of resuscitation, even though debunked by two prospective trials [23, 24], meant excessive crystalloid and colloid infusion. Group 1 consisted of 47 patients who received mesh at initial celiotomy, and group 2, 26 patients who received mesh at a subsequent celiotomy. These two groups were sta- tistically similar in demographics, injury severity, and mortality. However, group 2, compared with group 1, had a signifcantly higher incidence of postoperative abdominal compartment syndrome (35 versus 0%), necrotizing fasciitis (39 versus 0%), intra-abdominal abscess/peritonitis (35 versus 4%), and enterocutaneous fs- tula (23 versus 11%) (p < 0. Ivatury and associates  had been studying patients with catastrophic pene- trating trauma undergoing damage control procedures from 1992 to 1996. Further advances were also realized through the efforts of a remarkable group of clinical researchers interested in the subject. The efforts of anticipation of the complication, measures of prophylaxis, and earlier recognition and intervention all soon bore fruits: fewer organ failures and better survival. They also documented that abdominal decompression does not prevent return to gainful employment and should not be considered a permanently disabling condition. Another study  surveyed Dutch surgeons with a literature-based and expert consensus survey.
So buy norfloxacin 400 mg lowest price, for instance norfloxacin 400 mg free shipping, administering an anti- infammatory agent norfloxacin 400mg fast delivery, the once-believed holy grail of sepsis treatment best 400 mg norfloxacin, will not prove benefcial if the pro-infammatory phase has largely abated. Young, healthy rodents without comorbidity are predominantly used, and they often receive the septic insult that is non-representative of a clinical situation such as a bolus injection of endotoxin. The animals subsequently receive no or minimal or minimal standard sepsis management such as fuid . Furthermore, the treatment is often given before, concurrent with or soon after the septic insult, and the model duration is relatively short and thus does not account for late deaths. Those with some awareness often use outdated and fundamentally incorrect terminology such as blood poisoning and 12 L. These terms were intended to refect the presence of microorganisms in blood, yet this fnding is infrequently made in most patients, especially if they have received prior antibiotics. Likewise, patients with bacteraemia, viraemia or parasitaemia do not necessarily have sepsis. Better education of healthcare workers regarding the nature of sepsis, including earlier identifcation and optimal treatment, should improve out- comes. This is particularly relevant in view of the rising incidence of sepsis as the population ages and more aggressive medical interventions are given. Better tech- nologies to accurately identify infection and the causative agent and the early onset of organ dysfunction are needed, as are theranostics to guide choice and dosing of treatment. New treatments will be developed, but it is also worth reinvestigating discarded therapies as many may have a role in selected patients. It is also important to use a common language to describe incidence and epidemiology more precisely than at present. As more people survive sepsis, attention must also be paid to long- term outcomes, including morbidity, which can signifcantly impair quality of life and increase long-term healthcare costs. The Third International Consensus Defnitions for Sepsis and Septic Shock (Sepsis-3). Mortality related to severe sepsis and sep- tic shock among critically ill patients in Australia and New Zealand, 2000–2012. Principles and practice of medicine designed for the use of practitioners and students of medicine. On the antibacterial action of cultures of a Penicillium, with special reference to their use in the isolation of B. Intensive care medicine is 60 years old: the history and future of the intensive care unit. Defnitions for sepsis and organ failure and guide- lines for the use of innovative therapies in sepsis. Sepsis pathophysiology, chronic critical illness, and persistent infammation-immunosuppression and catabolism syndrome. Incidence, risk factors, and attrib- utable mortality of secondary infections in the intensive care unit after admission for sepsis. On behalf of the working group on sepsis- related problems of the European Society of Intensive Care Medicine. Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Multiorgan failure is an adaptive, endocrine-mediated, metabolic response to overwhelming systemic infammation. Etiology of illness in patients with severe sepsis admitted to the hospital from the emergency department. Genomic landscape of the individ- ual host response and outcomes in sepsis: a prospective cohort study. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Diabetes is not associated with increased 90-day mortality risk in critically ill patients with sepsis. Effect of statin therapy on mortality from infection and sepsis: a meta-analysis of randomized and observational studies. Effect of heart rate control with esmolol on hemody- namic and clinical outcomes in patients with septic shock. Prior use of calcium channel blockers is associ- ated with decreased mortality in critically ill patients with sepsis: a prospective observational study. Clinical characteristics, sepsis interventions and out- comes in the obese patients with septic shock: an international multicenter cohort study. Persistent infammation and immunosuppression: a common syndrome and new horizon for surgical intensive care. Rehabilitation interventions for postintensive care syndrome: a systematic review. However, this estimate is based on the incidence of hospital-treated sepsis in the developed world and may underesti- mate the true global burden of sepsis. Thirty to forty percent of cases are culture negative, and 20% have multiple pathogens identifed. This chapter will review the epi- demiology of sepsis, including incidence, etiology, long-term outcomes, and risk H. Throughout this chapter, sepsis refers to infection complicated by acute organ dysfunction, consistent with updated Sepsis-3 terminology, or what was previously termed “severe sepsis” in the 1992 and 2001 consensus defnitions [2, 3]. The Global Burden of Diseases Study—a worldwide observational epidemiological study that quantifes the burden death and disability due to specifc diseases—does not include sepsis as its own category, except in infants. From this, we can conclude that sepsis is a lead- ing cause of death and disability, although the exact magnitude of burden is unknown. However, the incidence varied widely across studies, from 90 to more than 1000 cases per 100,000 person-years, depending on the time-period of the study, country of origin, and method used to identify sepsis. However, by extrapolating from the avail- able studies from developed countries, the authors estimated that—among 7. This estimate assumes that the incidence of sepsis in lower-income countries is the same as the incidence of hospital-treated sepsis in developed countries. However, the incidence of infection is higher in lower-income countries, so the 19. Nonetheless, while the precise impact of sepsis has been diffcult to quantify, there is growing awareness that sepsis is a leading cause of death and disability and 2 The Epidemiology of Sepsis 17 that it has not received suffcient attention. In May 2017, in recognition of the global burden of sepsis, the World Health Organization adopted a resolution on improving the prevention, recognition, and management of sepsis . The resolution recog- nizes sepsis as a global health priority and urges member states to develop national policies and process to address sepsis . Rates of sepsis are moderate in infants (5 per 1000 people), are lowest in children and young adults (<5 per 1000 people), and then rise exponen- tially from ages 50 to 85 years and beyond . In developed countries, most (58%) sepsis hospitalizations and most sepsis-related hospital deaths (71%) are in patients aged 65 years or older . The greater incidence of sepsis in older patients is likely explained by both a greater prevalence of chronic medical conditions that may pre- dispose patients to sepsis (e. In studies using administrative data, the case-fatality rate of sepsis appears to increase steadily with age, from less than 10% in infants to more than 35% in patients 85 years and older . Some of this change is explained by temporal trends in the recognition and coding of sepsis, with increased labeling of less severely ill patients as septic over time —a condition known as stage migration, or “Will Rogers” phenomenon . However, even studies with stable sepsis defnitions fnd that the incidence of sepsis is rising over time, albeit more modestly . For example, in one study that identifed sepsis based on clinical evidence of infection and organ dysfunction in electronic medical records, septic shock cases rose from 12. Prescott The rising incidence of sepsis is likely multifactorial, related to both better sur- vival from other medical conditions such as cancer and increasing use of immuno- suppressive therapies and invasive medical procedures, which together result in a greater number of patients who are at heightened risk for developing sepsis. Beyond those gradual changes in sepsis incidence and mortality from year to year, the incidence and lethality of sepsis also vary by season. Both incidence and case-fatality rates are about 17% higher in the winter months and show greater fuc- tuations in cold climates . This difference is largely explained by differences in pulmonary infection, as respiratory causes of sepsis increase about 40% during win- ter months . For example, the incidence of sepsis is approximately 40-fold higher in patients on maintenance hemodialysis compared to patients not on hemodialysis . Sepsis incidence is also four- to tenfold higher in cancer patients than non-cancer patients and higher still in patients with certain malignancies (e. In addition to higher incidence rate, the case fatality of sepsis also varies by the presence of comorbid conditions and is 55% greater in patients with cancer .
Figure 56-6 Target points (A) and expected lesions (B) from water-cooled radiofrequency denervation at the right L5 medial branch and the S1 discount norfloxacin 400mg online, S2 purchase norfloxacin 400mg overnight delivery, and S3 lateral branches buy 400 mg norfloxacin free shipping. Randomized placebo-controlled study evaluating lateral branch radiofrequency denervation for sacroiliac joint pain proven 400 mg norfloxacin. Local anesthetic and steroid injections into the piriformis muscle may break the pain/muscle spasm cycle. A randomized study noted similar efficacy of the fluoroscopy- and ultrasound-guided piriformis injections. There appears to62 be no difference between lidocaine and lidocaine with betamethasone. If63 relief from the local anesthetic does not last, then the piriformis muscle is injected with 100 units of botulinum toxin A in 2 to 3 mL of local anesthetic. The trigger point can be felt as a palpable taut band and manipulation of the trigger point by digital pressure or by penetration by a needle may induce a twitch response. There is spot tenderness in the taut band; pressure on the tender nodule induces pain that the patient recognizes as an experienced pain pattern, and there may be limitation to full passive range of motion of the affected muscle. The management of myofascial pain syndrome includes repeated applications of a cold spray over the trigger point in line with the involved muscle fibers, followed by gentle massage of the trigger point and stretching of the affected muscle. Physical therapy includes improving posture, body mechanics, relaxation techniques, trigger point massage, postisometric relaxation, and reciprocal inhibition. A part of a multimodal treatment is local anesthetic injection or dry needling of the trigger point. Recent studies show that dry needling may be as effective as local anesthetic injection; however, the local anesthetic makes the procedure less painful. Several injections at 2- to 3-week intervals, followed by physical therapy, may result in a long-term benefit. Botulinum toxin injections have been recommended but the results of clinical studies have not been uniform. In a study using an enriched protocol design (two groups randomized into botulinum toxin and placebo groups after the patients responded to an initial botulinum toxin injection), better pain scores and a reduced number of headaches were observed in the patients injected with botulinum toxin. The tender points are located in the occiput, the intertransverse spaces between C5 and C7, trapezii, supraspinatus, the second rib (just lateral to the costochondral junctions), lateral epicondyles, glutei, greater trochanters, and knees. Also, family members of fibromyalgia patients are more likely to have irritable bowel syndrome, temporomandibular disorders, headaches, and a host of other regional pain syndromes. The increased activity of endogenous70 opioidergic systems explains clinicians’ observations that opioids are ineffective in this syndrome. The optimal treatment of fibromyalgia supports a multifaceted program comprising pharmacologic and nonpharmacologic therapy. Neuropathic Pain Syndromes Herpes Zoster and Postherpetic Neuralgia Some patients with acute herpes zoster have a prodrome of dermatomal pain before the skin eruptions. The pain of acute herpes zoster is usually moderate in severity and can be managed with analgesics, and the pain usually subsides with healing of the rash. Most of the studies on the efficacy of neuraxial and peripheral nerve blocks, performed during the acute stage of herpes zoster, have been either retrospective or case series. However, more reliable prospective randomized controlled studies provide conflicting results. A study in which epidural methylprednisolone and bupivacaine was compared with acyclovir and prednisolone showed the epidural steroid group to have less pain (1. Another study in which76 standard therapy with oral antiviral medications and analgesics was compared 4043 with standard therapy and epidural methylprednisolone and bupivacaine noted less pain in the epidural group (48% vs. The better results in this study may be related to the77 greater number of epidural injections (two to four vs. Although the antidepressants have been found to be effective, their use is precluded by the frequent occurrence of side effects. The side effects include anticholinergic effects such as tachycardia, dry mouth, constipation, and symptoms of prostatism in elderly males. Nortriptyline is preferred over amitriptyline because it is equally effective and better tolerated. Two studies showed that the combination of gabapentin and controlled-release morphine, and gabapentin and nortriptyline, were more effective and required lower daily dosages than when either drug was given alone. When quality of life, side effects, prevention of addiction, and regulatory issues are considered important in addition to pain relief, then gabapentin/pregabalin may be the first drugs of choice. The incidence of diabetic neuropathy increases with duration of diabetes, age, and degree of hyperglycemia; neuropathies generally develop after persistence of hyperglycemia for several years. The pathophysiology of diabetic neuropathy includes the polyol pathway, microvascular, and glycosylation end-product theories. Ketamine can be given either as a 4- to 5-day infusion at 194 4045 to 7 μg/kg/min (5 to 30 mg/hr in a 70-kg patient) or for 4 hours daily for 10 days at an infusion rate of 0. The neuropathy and dysesthesia progress from the distal to the more proximal structures. There is minimal subjective or objective motor involvement and this is generally limited to the intrinsic muscles of the foot. The onset of pain may be immediate but commonly occurs within the first few days following amputation. Approximately 50% of patients experience a decrease of their pain with time, whereas the other 50% report no change or an increase in pain over time. Peripheral mechanisms include neuromas, an increase in C-fiber activity, and sodium channel activation. Central mechanisms include abnormal firing of spinal internuncial neurons and supraspinal involvement secondary to the development of new synaptic connections in the cerebral cortex. Numerous prophylactic measures have, with variable success, been 4046 undertaken in an attempt to reduce the incidence of phantom limb pain. These include perioperative epidural infusions of opioids and local anesthetics or clonidine, and continuous brachial plexus blockade with memantine. The treatment of phantom limb pain includes pharmacologic and nonpharmacologic measures. A systematic review noted level 2 evidence for the effectiveness of gabapentin, morphine, tramadol, intramuscular botulinum toxin, and epidural ketamine. A combination of pharmacologic treatment with physical, psychological, or behavioral intervention is probably the most effective approach. Cancer Pain Significant pain is present in up to 25% of patients with cancer who are in active treatment and in up to 90% of patients with advanced cancer. Management of cancer pain should be multifaceted and include the following: (1) appropriate tumor-specific antineoplastic therapy, (2) pain medications, (3) interventional management, (4) behavioral and psychological management, and ultimately (5) hospice care. Opioids are the mainstay of treatment for cancer pain as approximately 75% to 95% of patients are responsive positively when appropriate guidelines are followed. Continuous intravenous opioid infusions can be performed during the later stages of the disease. Interventional treatments include neurolytic sympathetic nerve blocks and intrathecal opioids. Vertebroplasty or kyphoplasty may be required for vertebral compression syndromes. Neurolytic Blocks for Visceral Pain from Cancer Celiac Plexus Block The celiac plexus innervates all of the abdominal viscera except the left side of the colon and the pelvic viscera. The plexus contains two large ganglia that receive sympathetic fibers from the greater, lesser, and least splanchnic 4047 nerves. The splanchnic nerves are located retroperitoneally at the level of the T12 and L1 vertebrae, and the celiac plexus is anterior to the crura of the diaphragm and surrounds the abdominal aorta and the celiac and superior mesenteric arteries. Blockade of the celiac plexus can be achieved by the classic retrocrural approach, an anterocrural approach, or by neurolysis of the splanchnic nerves. In the retrocrural approach, the tip of the needle is advanced approximately 1 cm anterior to the anterior and upper border of L1. In the anterocrural or transaortic approach, the tip of the needle is advanced through the lower portion of L1 and the aorta on the left side until blood can no longer be aspirated through the needle. For splanchnic nerve block, the tip of the needle is placed at the anterior portion of the T12 vertebral body. Better results are usually seen with local anesthetics because of better spread (phenol is viscous and its vascular absorption may relieve pain). The dosages of the neurolytic agents are 30 to 40 mL for the retrocrural and anterocrural approach, and 10 to 15 mL on each side for splanchnic nerve blockade. Complications from the celiac plexus block include orthostatic hypotension, back pain, retroperitoneal hematoma, reactive pleurisy, hiccups, hematuria, transient diarrhea, abdominal aortic dissection, transient motor paralysis, and paraplegia. The paraplegia and transient motor paralysis may be due to spasm of the lumbar segmental arteries that perfuse the spinal cord, direct vascular or neurologic injury, or retrograde spread to the nerve roots or spinal cord.
Its motor nucleus is located on the border betweenthe upper part of the rhomboid fossa and the pons buy norfloxacin 400mg line. Fibers go out of these cores to the top of the temporal bone pyramid where the trigeminal node can be found in the splitting of the dura mater buy generic norfloxacin 400 mg. Terminal branches of the frontal nerve are the supraorbital branch discount 400 mg norfloxacin amex, that exits through the sulcus or foramen supraorbitaie discount norfloxacin 400mg amex, innervating the skin of the forehead, and the supratrochlear branch that innervates the skin of the upper eyelid. Nasolacrimal nerve is divided into three branches: the front and rear ethmoidal nerves penetrate into the nasal cavity through nasal foramen; lower block nerve innervates the skin of the lower eyelids (Fig. Nervus maxillaris - maxillary nerve which passes through the round hole of the skull base and divides into the following branches: - n. It passes through the infraorbital fissure, then goes through the canalis infraorbitalis and forms a so-called “smaller goose foot”, which is located within the fossa canina. Symptoms of trigeminal nerve are hypersthesia, anesthesia or hyposthesia localized in zones of innervation of the trigeminal nerve, paralysis of the masticatory muscles; pain in the exit points of the nerve branches: foramen supraorbitale, foramen infraorbitale, fossa canina and foramen mentale; lockjaw when there is a damage of mandibular branches as a result of hematomic compression hematoma originating from face wounds; trophic keratitis. It passes through fissura orbitalis superior and innervates the lateral rectus muscle of the eye. In case of inflammation of the pars petrosa of the temporal bone (petrositis), which can happen as a consequence of the inflammation of the middle ear, there is a chance of symptoms of the abducens and the oculomotor nerves. This symptom complex is called Gradenigo syndrome - the immobility of the eyeball. It goes through the internal auditory canal, and after that it proceeds into the facial canal of the temporal bone. Together with the lingual nerve it innervates the frontal two-thirds of the tongue. After exiting the foramen stylomastoideum facial nerve pierces the parotid-masticatory gland, within which it forms a “big goose foot”: rami temporaiis go to the frontal muscle, rami zygomatici – to the circular muscles of the eye, rami buccalis - to the facial muscles persons, ramus marginalis mandibulae – goes on to the edge of the lower jaw and innervates the m. Symptoms associated with the facial nerve: Prosopoplegia homolateralis – loss of function of facial muscles on one side with shift to the healthy side. Symptoms of vestibular-auditory nerve: in case of fracture of the skull base with damage dealt to the temporal bone pyramid all three nerves passing in the inner ear canal are also damaged: n. Symptoms of the vagus nerve: if it is damaged above the recurrent nerve - disturbance of cardiac activity, respiration, loss of functions of the larynx, as well as its sensitive paralysis. It starts branches of motor innervation of sternohyoid, grudinoschitovidnoy, scapular-hyoid and thyroid muscles. Symptoms of the hypoglossal nerve: tilt of the tongue to the damaged side, atrophy of muscles innervated by n. Tunicas of the brain: 1) dura mater, 2) the arachnoid membrane - tunica arachnoidea, 3) pia mater (tunica vasculosa). Epidural and intrathecal space: 1) spatium epidurale - space above the dura, 2) spatium subdurale - space underneath the dura, 3) spatium subarachnoidale - subarachnoid space, although sometimes this space forms an extension - subarachnoid cisterns with a large quantity of cerebrospinal liquid. Specifics of arterial blood supplying and backflow of venous blood from the brain. The blood supply of the brain is carried out using branches of four arteries: the two internal carotid arteries and two vertebral arteries (Fig. Carotis interna) detaches from the common carotid artery at the level of the upper edge of the thyroid cartilage. There are also some smaller branches of coming to the middle front gyrus, a precentral, postcentral gyrus and superior parietal lobule. After ascending up the slope, both vertebral arteries begin lower cerebellar arteries (aa. Communicans posterior) goes from the posterior cerebral artery to the internal carotid artery. Arterial circle of the cerebrum, circulus arteriosus cerebri (Willisii) is made of: up front - of the unpaired anterior communicating artery (a. Communicans anterior), from the anterolateral side - of the anterior cerebral artery (a. Inside the cranial cavity blood flowing from the brain through the veins enters the sinuses of dura (Fig. Dural sinuses communicate with the veins of soft tissues of the head and diploic veins using emissary veins (vv. Figure 13 Dural venous sinuses 1 – sinus sagitalis inferior; 2 – sinus sagitalis superior; 3 – sinus rectus; 4 – torcular herofili; 5 – sinus transverses; 6 – sinus sigmoideus; 7 – bulbus venae jugularis; 8 – v. This system consists of the system of the ventricles and the subarachnoid space belonging to the brain and the spinal cord. The side (lateral) ventricles (vertriculi lateralis) lie in the depths of both hemispheres of the brain. There are the left lateral ventricle (ventriculus lateralis sinister) and right lateral ventricle (ventriculus lateralis dexter), both which are placed in the respective hemispheres. Both lateral ventriculi have an anterior horn (cornu anterius), the central part (pars centralis), posterior horn (cornu posterius) and lower horn (cornu inferius). It is surrounded with the pons and with the medulla oblongata from the front and with the cerebellum from the back and the sides. The rear portion of the fourth ventricle has two side apertures (apertura lateralis ventriculi quarti), or Luschka’s holes, through which the ventricular cavity gets connected with the subarachnoid space. Choroid plexus of the ventricular system are the main source of cerebrospinal fluid (70-85%). The backflow of liquid from it is performed using filtration into the venous system - into sinuses of the dura mater, where blood comes through the arachnoid granulations. Backflow also partially goes on through the lymphatic system and the perivascular perineural fissures that connect with the subarachnoid space. The head skin surface projection of the gyri and the main sulci of the cerebral cortex, the brain ventricles, the middle meningeal artery and its branches, dural venous sinuses: using Krönlein method, the following lines are supposed to be drawn: sagittal, lower horizontal, top horizontal, front vertical, middle vertical, rear vertical. In order to locate Rolando’s sulcus it is necessary to draw a line connecting the point of intersection of the first vertical line and and upper horizontal line with the upper point of intersection of the rear vertical and sagittal lines. Sylvian fissure is projected by the bisecting of the angle composed of the projection line Rolando’s sulcus and upper horizontal line. Sinus sagittalis is projected on the sagittal line, sinus transversus - across lin. The lateral ventricles are projected within the semi-circle with the radius equal to half of the distance between the external auditory canal and the sagittal line; in this case the external auditory canal is considered to be a center. The fourth ventricle is arranged in such a way so its short diagonal line falls a little bit below and in parallel to lin. Surgical Anatomy of Congenital Disorders Brain hernias are development of the specific type disorders of the skull and the brain characterized by a defect in the frontal or occipital bone which serves as hernia gate and lets brain matter fall through it. The following types of brain hernias exist: meningocele, encephalocele and entsefalotsistotsele. Meningocele happens when arachnoid and soft tunicas pass through a hole in the cranial bones. Hydrocephalus is the dilatation of the ventricular system of the brain and subarachnoid spaces caused by excessive amount of cerebrospinal fluid. Congenital form is characterized by the increase in the circumference of the skull at birth, alteration of body/head ratio, noticeable increase of the size of suturas, and larger fontanelles. The forehead is higher than usual, overhanging, facial skeleton is relatively smaller, eyelids are half-closed. Pathotopography of the Cerebral Part of the Head Hemorrhage in the brain due to aneurysm rupture (Fig. Figure 17 Bleeding in the brain due to rupture of the aneurism 1 - rupture of the artery; 2 - ruptured aneurysm (the circle of Willis); 3 - subarachnoid hemorrhage (blood comes from a torn aneurysm); 4 - compression of the temporal lobe blood coming from a torn aneurysm Subarachnoid hemorrhage is a sudden bleeding to the subarachnoid space. Hemorrhage occurs as a result of the release of blood from the ruptured aneurysm into the space between the arachnoid and the soft meninges. The most common cause is a traumatic brain injury, but traumatic subarachnoid hemorrhage is considered as an independent nosology. Spontaneous (primary) subarachnoid hemorrhage in about 85% of cases is due to rupture of intracranial aneurysms, most often congenital saccular or grozdepodobnyh. Aneurysm rupture can occur at any age, but more often occurs at the age of 40-60 years.